BWangBing Wang, PhD
Global Discovery Chemistry
Cambridge, Massachusetts, United States

The biological membrane is an important specialized interface in organisms that plays critical roles in biological processes via a complex interplay between lipid molecules and other molecules (protein, peptides, small molecules, etc.). One of the research goals in drug discovery is to design and synthesize drug molecules with good membrane permeability for efficient drug uptake through oral administration and for drug efficacy while targeting intracellular targets. However, the detailed mechanisms of how molecules interact with and permeate membranes remain poorly understood. We want to gain fundamental understanding of the structure-property relationships of membrane permeability at the molecular level by studying molecular conformations and interactions, using nuclear magnetic resonance spectroscopy (NMR). Solid-state NMR has the advantage of elucidating the anisotropic properties of the membrane and determining molecular interactions and three-dimensional structures in bilayers. We believe that gaining detailed knowledge of the interactions between membranes and other molecules (such as small molecules, peptides and proteins) and relevant 3D structures will benefit not only the fundamental understanding of biophysical and biochemical properties of the membrane and its interacting molecules, but also the design of better drugs.

Selected Publications

Stereochemical Control of Nonamphiphilic Lyotropic Liquid Crystals: Chiral Nematic Phase of Assemblies Separated by Six Nanometers of Aqueous Solvents
Yang S, Wang B, Cui D, Kerwood D, Wilkens S, Han J, Luk Y.
J Phy. Chem. B. 2013 May; 117(23):7133-43

4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding
LaMarche MJ, Leeds JA, Dzink-Fox J, Gunderson K, Krastel P, Memmert K, Patane MA, Rann EM, Schmitt E, Tiamfook S, Wang B.
J. Med. Chem. 2011 March;54(7):2517-21

Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors.
Yamashita DS, Marquis RW, Nidamarthy S, Xie R, Oh, H-J, Jeong JU, Erhard KF, Ward KW, Roethke TJ, Simith BR, Cheng, H-Y, Geng, X, Lin F, Offen P, Wang B,
J. Med. Chem. 2006 Feb; 49 (5): 1597-1612.

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