davidglassDavid Glass, MD
Chemical Biology & Therapeutics
Cambridge, Massachusetts, United States


Our research interests focus on:

  1. mechanisms underlying aging of skeletal muscle and the neuromuscular junction
  2. mechanisms of skeletal muscle hypertrophy and atrophy
  3. mechanisms of muscle energetics
  4. secreted factors that are perturbed by age, and which might mediate bioenergetics and senescence
  5. mechanisms causing cellular senescence

Selected Publications

A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation.
Gong C, Li Z, Ramanujan K, Clay I, Zhang Y, Lemire-Brachat, S, Glass DJ.
Dev Cell. 2015 Jul; 34: 181-191.

GDF11 increases with age and inhibits skeletal muscle regeneration.
Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ.
Cell Metabolism. 2015 Jul; 22: 164–174.

ATP citrate lyase improves mitochondrial function in skeletal muscle.
Das S, Morvan F, Jourde B, Meier V, Kahle P, Brebbia P, Toussaint G, Glass DJ, Fornaro M.
Cell Metabolism. 2015 Jun; 21: 868-876.

Gαi2 signaling is required for skeletal muscle growth, regeneration and satellite cell proliferation and differentiation.
Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M.
Mol Cell Biol. 2014 Feb; 34: 619-630.

Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.
Li Z, Zhang Y, Ramanujan K, Ma Y, Kirsch DG, Glass DJ.
Cancer Research. 2013 May; 73: 3041-3050.

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia.
Ibebunjo C, Chick JM, Kendall T, Eash JK, Li C, Zhang Y, Vickers C, Wu Z, Clarke BA, Shi J, Cruz J, Fournier B, Brachat S, Gutzwiller S, Ma Q, Markovits J, Broome M, Steinkrauss M, Skuba E, Galarneau JR, Gygi SP, Glass DJ.
Mol Cell Biol. 2013 Jan; 33(2):194-212.

An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.
Li Z, Gilbert JA, Zhang Y, Zhang M, Qiu Q, Ramanujan K, Shavlakadze T, Eash JK, Scaramozza A, Goddeeris MM, Kirsch DG, Campbell KP, Brack AS, Glass DJ.
Dev Cell. 2012; 23(6):1176-1188.

MNK2 inhibits eIF4G activation through a pathway involving serine/arginine-rich protein kinase in skeletal muscle.
Hu SI, Katz M, Chin S, Qi X, Cruz J, Ibebunjo C, Zhao S, Chen A, Glass DJ.
Science Signaling. 2012 Feb; 5(211):ra14.

The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling
Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ.
Dev Cell. 2011 Nov; 21(5):835-847.

Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration.
Minetti GC, Feige JN, Rosenstiel A, Bombard F, Meier V, Werner A, Bassilana F, Sailer A, Kahle P, Lambert C, Glass DJ, Fornaro M.
Science Signaling. 2011 Nov; 4(201):ra80.

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Application Steps