GJurisicGiorgia Jurisic, PhD
(Co-Mentor: Klaus Seuwen, PhD)

Chemical Biology & Therapeutics
Basel, Switzerland

Our research focuses on the blood and lymphatic vascular systems and their role in inflammatory diseases and tissue regeneration. The lymphatic vascular system in particular has emerged in recent years as an important regulator of tissue homeostasis, while the molecular mechanisms that govern its development and maintenance of function in the adult are still poorly understood.

Using complex assays with primary human cells and tissues, animal models, and applying state of the art profiling technologies, we investigate two aspects of the lymphatic system: lymphangiogenesis and endothelial barrier function. Sprouting lymphangiogenesis, where new vessels are created from pre-existing ones to allow for enhanced lymphatic fluid drainage, is a major form of tissue lymphatic neovascularization. We aim to discover novel factors that affect endothelial differentiation and vessel functionality and to expand our knowledge on the molecular pathways involved. Furthermore, the tightly controlled barrier formed by lymphatic endothelial cells directly influences fluid absorption and transport as well as immune cell trafficking. Early evidence is showing that lymphatic endothelial barrier is disrupted in inflamed tissue. By increasing the functionality of vasculature we aim to improve tissue regeneration and by this approach open new therapeutic directions.

Selected Publications

Giorgia Jurisic

Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement.
Jurisic G, Sundberg JP, Detmar M.
Inflamm Bowel Dis. 2013 Aug;19(9):1983-9.

An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation.
Jurisic G, Maby-El Hajjami H, Karaman S, Ochsenbein AM, Alitalo A, Siddiqui SS, Ochoa Pereira C, Petrova TV, Detmar M.
Circ Res. 2012 Aug 3;111(4):426-36.

Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease.
Jurisic G, Sundberg JP, Bleich A, Leiter EH, Broman KW, Buechler G, Alley L, Vestweber D, Detmar M.
Genes Immun. 2010 Apr;11(3):219-31.

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Klaus Seuwen

Oxysterols direct immune cell migration via EBI2.
Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW.
Nature. 2011 Jul 27;475(7357):524-7. doi: 10.1038/nature10280.

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Mullershausen F, Zecri F, Cetin C, Billich A, Guerini D, Seuwen K.
Nat Chem Biol. 2009 Jun;5(6):428-34. doi: 10.1038/nchembio.173.

Proton-sensing G-protein-coupled receptors.
Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K.
Nature. 2003 Sep 4;425(6953):93-8.

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