Giorgio G. Galli, PhD
(Co-Mentor: Dirk Schübeler, PhD)
Across our genome, DNA elements with non-coding, yet key regulatory function, harbor characteristic epigenetic signatures that ultimately impact transcriptional output. In particular, a subset of enhancer elements termed super-enhancers (SEs) have been shown to drive exceptionally high transcription of genes essential for cell identity and tumorigenesis. SEs are densely contacted by a critical transcription factor (TF) network referred to as “Core Regulatory Circuitry (CRC)”. Interestingly, CRCs have been shown to sub-classify specific cancer types, thereby revealing options for therapeutic intervention.
Our laboratory is interested in characterizing such CRCs in cancer subtypes bearing specific genetic lesions. To this end, we extensively perform functional genomics studies to interrogate the dependency of cancer models on oncogenic TFs, their pathway modulators and target genes in order to identify novel cancer vulnerabilities. Moreover, we perform epi-/genomic and proteomic profiling on novel TFs/CRCs to further characterize the molecular mechanisms underlying their oncogenic role.
We are working in close collaboration with different departments within NIBR, as well as with Dirk Schuebeler’s lab at the FMI (Postdoc Co-Mentor) and Charles Lin’s lab at the Baylor College of Medicine.
YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.
Galli GG, Carrara M, Yuan WC, Valdes-Quezada C, Gurung B, Pepe-Mooney B, Zhang T, Geeven G, Gray NS, de Laat W, Calogero RA, Camargo FD.
Mol Cell. 2015 Oct 15;60(2):328-37.
The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.
Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD.
Cancer Cell. 2014 Aug 11;26(2):273-87.
Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone.
Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Calogero RA, Couchman JR, Lund AH.
PLoS Genet. 2012;8(5):e1002711..
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