JBaryzaJeremy Baryza, PhD
Global Discovery Chemistry
Cambridge, Massachusetts, United States

Our research group works to understand how to modulate RNA biology and function as a way to correct disease processes. Broadly speaking, we are interested in modulating RNA function directly by modulating the structure and recognition of RNA molecules. With our increasing understanding of the central role that RNA and RNA structures can play in disease, we want to develop the understanding and tools to modulate these targets directly in vitro and in vivo to better characterize and treat diseases where RNA biology plays a central role.

One aspect of this work is the development of new methods towards modulating miRNA by selectively targeting miRNA biogenesis with small molecules and other reagents. Another aspect is targeting known toxic RNA structures as a way to reduce their disease-causing effects. Combined with these efforts we are collaborating with groups to better understand RNA recognition and function in cells and animals and to develop high-throughput methods for determining RNA structures and interactions. Ultimately, we aim to develop methods for the identification of regulatory motifs in RNA and the tools to modulate these motifs directly.

Selected Publications

Biodistribution and metabolism studies of lipid nanoparticle-formulated internally [3H]-labeled siRNA in mice.
Christensen J, Litherland K, Faller T, van de Kerkhof E, Natt F, Hunziker J, Boos J, Beuvink I, Bowman K, Baryza J, Beverly M, Vargeese C, Heudi O, Stoeckli M, Krauser J, Swart P.
Drug Metab Dispos. 2014 Mar;42(3):431-40.

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity.
Wender PA, Baryza JL, Brenner SE, DeChristopher BA, Loy BA, Schrier AJ, Verma VA.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6721-6.

Multiple cyclophilins involved in different cellular pathways mediate HCV replication.
Gaither LA, Borawski J, Anderson LJ, Balabanis KA, Devay P, Joberty G, Rau C, Schirle M, Bouwmeester T, Mickanin C, Zhao S, Vickers C, Lee L, Deng G, Baryza J, Fujimoto RA, Lin K, Compton T, Wiedmann B.
Virology. 2010 Feb 5;397(1):43-55.

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