Maroof Hasan, MD, PhD
(Co-Mentor: Juan Zhang, PhD)
Autoimmunity, Transplantation and Inflammation
Autoimmune diseases (AID) are often complex and characterized by heterogeneous clinical phenotypes and diverse pathological consequences. Multiple factors contribute to disease pathogenesis and organ-specific manifestations. In order to develop innovative therapies, better understanding of the disease mechanisms is essential. Patients with complex AID also present with dysregulation of metabolic pathways including oxidative stress and energy metabolism. The pathological consequences of these alterations, however, remain unclear.
The focus of our future studies is to uncover novel mechanisms involved in immunometabolic regulatory pathways, identify useful biomarkers, and develop novel innovative approaches for better patient characterization and selection of effective therapeutics. We employ cutting-edge technologies such as transcriptomics and metabolomics together with immune profiling to explore the complex interplay between immunometabolic factors and how such factors act in concert for the development of organ-specific pathologies.
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N.
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):746-751.
Cytosolic nuclease TREX1 regulates oligosaccharyltransferase activity independent of nuclease activity to suppress immune activation.
Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.
Immunity. 2015 Sep 15;43(3):463-74.
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N.
Nat Immunol. 2013 Jan;14(1):61-71.
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