Reshma Singh, PhD
(Co-Mentor: Alicia Carlson, PhD)
Cambridge, Massachusetts, United States
Previous work has shown that immune cells and tumors interact in several ways that allow for either the activation of T cells or the suppression of T cell function. The Singh lab studies the in vivo efficacy and characterization of CAR (chimeric antigen receptor) T cells, and is working to characterize the engraftment and expansion of the T cells. The Carlson lab develops imaging methods and techniques to study the interactions of cells in a live animal. Together, we will be able to set up a global evaluation of tumor burden and T cell dissemination via bioluminescent imaging as well as study cell localization and cell-to-cell interactions through multi-photon intravital fluorescence microscopy. This project will involve not only studying the biology of T cell responses, but also developing and adapting methods of imaging and image analysis to capture this in real time in live mice.
Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer.
Hannan R, Zhang H, Wallecha A, Singh R, Liu L, Cohen P, Alfieri A, Rothman J, Guha C.
Cancer Immunol Immunother. 2012 Dec; 61(12): 2227-38.
Defective crosspresentation of viral antigens in GILT-free mice.
Singh R and Cresswell P.
Science 2010 Jun;328(5984): 1394-8.
Immunoediting sculpts tumor epitopes during immunotherapy.
Singh R and Paterson Y.
Cancer Res. 2007 Mar;67(5): 1887-92.
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